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Covaris Fragmentation

The GBCF provides DNA fragmentation services using the Covaris S220 Ultrasonicator System. Nucleic acid fragmentation is applicable to many applications including DNA sequencing library preparation, chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization. Ultrasonication is favored over other fragmentation methods because DNA molecules are randomly broken with minimal bias.

Service Rates

View internal and external service rates.  

New Policies and Procedures

Effective January 01, 2021


External Users: Contact Melissa Stephens. We are accepting a limited number of requests until further notice.

Internal Users: Access Galvin Life Science Center via the main entrance during regular business days and hours. 

  1. iLab transition complete as of January 06, 2021. Go to InsideND and search for iLab Core Facility Management. GBCF iLab video tutorials and user guide available on Resource tab.

  2. Communicate with facility staff by email, phone, or Zoom appointment.

  3. Samples delivered contactless. Access to facility space is restricted to facility staff.  On designated days and reserved times, there will be a cooler outside the facility door to receive samples. Do not leave samples if the cooler is absent; we are not responsible for damage or loss.

Submitting Your Order

  1. Guidelines for Submission: Review and prepare samples accordingly.

  2. Excel Submission Form: Download and complete all fields. REQUIRED: Attach it to iLab service request. 

  3. iLab Core Facility Management: Request service and reserve a sample drop-off day/time. iLab sends us a notification about service requests and scheduled reservations. Do not send us a separate email.

    • Go to InsideND, search for iLab Core Facility Management, and sign in using University of Notre Dame credentials.

    • Request service and attach your completed Excel Submission Form. Within the service request, include the email of other lab members who should be consulted or notified with results. 

    • Schedule a reservation 24 hours in advance by selecting a day and time from the Sample Processing Calendar.

      • REQUIRED: If you can not make your reservation, cancel it as soon as possible and select a new time slot.

      • Recommendation: Coordinate within your lab to reduce multiple deliveries to a single drop-off reservation whenever possible.

  4. Deposit the sample inside the cooler outside of the facility door on your reserved day and time.

Your Results

When your service request is completed, an email notification is sent to the person who created it.
Results are posted to the iLab Service Request. If permission is needed to access results, please indicate within the Excel Submission Form - Additional Information field.


The processed sample is returned contactless. We will schedule a day and time for pick-up using iLab Sample Processing Calendar.
For concentration and fragment size assessment, request Sample QC service separately.